A Novel Case-Based Research Strategy Brings Relevance to Studying Immunology and Clinical Immunology-a Case Study of Contact Dermatitis

Authors

Micova S
Vasileva S
Bojadzieva E and Stevceva L

Theme

Basic Sciences and Clinical Integration

INSTITUTION

Faculty of Medicine, University Goce Delcev, Stip, Macedonia
California Northstate University College of Medicine: http://www.cnucom.org

Background

In an attempt to enhance the learning experience in Clinical Immunology and to bring relevance to the basic scientific concepts that are taught, we introduced a novel CASE-BASED RESEARCH strategy to second year medical students at the Faculty of Medicine, University 'Goce Delcev' Stip, Macedonia. The Clinical Immunology course is an elective course and was chosen by 57 students. 

Briefly, at the beginning of the course students were given an option to choose their peers (maximum of three working on the same project) and to choose a medical practice/clinic, polyclinic and a physician that they would like to work with. They were given a list of immunologically mediated diseases and were instructed on how to conduct case-based research. The CASE-BASED RESEARCH consisted of two parts.

The first part was to select and shadow a physician for at least a month and to write a patient contact diary on one of the immunologically mediated diseases from start until resolution. Physicians could be chosen from the affiliated clinical faculty at the Medical School but also from community physicians in the area. Students were instructed on the proper informed consent procedures and confidentiality issues.  A list of immunologically mediated diseases, letter for the medical doctor and blank form for permission to be photographed were provided at the beginning of the course. Students were taught the proper consent procedure. 

The second part was to summarize their findings and to research and describe the underlying immunological disease emphasizing the mechanisms that led to the presenting clinical symptoms. This resulted in generation of a written paper. The submitted papers were accompanied with the certification from the collaborating physician that the student fulfilled the criteria of shadowing the physician for at least a month and that the patient described is indeed one of their patients.

This activity was optional and could bring up to 15 bonus points. Students needed to achieve a minimum 10 points in order to obtain the bonus points. The following criteria were used for grading:

Extent of details that describe the medical condition

Ability to link the clinical presentation with the basic immunological mechanism 

Extent and accuracy of details describing the underlying immune mechanism

Following proper consent procedures 

Appropriate and current references

Summary of Work

Participating in this project was optional but participation did offer a possibility to earn a maximum of 15 bonus points. The passing mark was 10 points. Students earning less then 10 points did not receive any bonus credit points. Thus, the number of bonus points that one could earn was from 10 to 15.

This activity was well received by the students. Majority of the students opted to pursue this activity (82.45%). Support was offered from the medical doctor that mentored them in the clinic and the faculty at the university. Some students required help in allocating a suitable clinic. The project offered a possibility to involve not just physicians at the faculty clinics but also community physicians and this was well received. The greatest challenge for the faculty was the process of guiding the students to proper resources to research and reference the literature. Because of very limited resources it was virtually impossible in many cases to provide them with full text of the articles or books. This is why referencing also web links finally had to be approved. Most of the Case Based Research papers required at least one correction with about 6% requiring multiple corrections.

An example of a Case Based Research paper generated this way is shown under Details.  Please, note that photographs used in this paper are not original photographs from the case described but are taken from textbooks, publications and internet. Sources of images are listed in the Bibliography.

Conclusion

Case-Based Research (CBR) achieved bringing case studies early in the curriculum and it combined practical experience, teamwork and learning the basics of writing a research paper. It also brought relevance to immunological concepts as it connected them with real life diseases. 

Take-home Messages

CBR could be implemented in several pre-clinical courses. Students enjoy it and it is a valuable, active learning experience. The greatest value of this approach is that it brings relevance to basic scientific concepts.

Caifornia Northstate University College of Medicine is a new medical school based in Sacramento area, California, USA that uses integrated curriculum. We anticipate our first class of medical students to start in 2014. We are currently hiring both clinical and basic science faculty. Interested individuals may apply on our web site http://www.cnucom.org and/or contact Prof. Liljana Stevceva at liljana.stevceva@cnucom.org.

Acknowledgement
Background

 
LETTER FOR THE MEDICAL DOCTOR
 

 

Dear colleagues,

The carrier of this letter is a second year student of the Faculty of Medicine, University Goce Delcev, Stip. Within the Clinical Immunology course the students have a task to get attached to a medical practice, clinic, policlinic and similar where they will shadow the doctor that will mentor them.  After that, the students should write a Case Based research paper for the course Clinical Immunology where they will describe a case of an immunologically mediated disease that they followed. Attached to the this letter you will find a list of diseases that might be immunologically mediated. When describing the case, students should write anamnesis, investigations that were done, differential diagnosis and final diagnosis. Then, they will research the literature about that disease and will discuss the immunological mechanisms involved in its pathogenesis.

It is expected that the cases described will be original cases from your medical practice. If the paper is successful and the case is interesting there is a chance that we may try to publish it in a medical journal with you as a co-author. If photographs of the patient are taken, we will need a written permission signed by the patient that will accompany the seminar thesis. The form for this is included with this letter.

We are hoping that you will be interested in helping us and that you will aloow the student carrier of this letter to work with you. We believe that this experience will be especially useful for these students.

If you agree to accept the student, we will ask you to please, sign this letter at the dotted line and include the details of your medical practice.

 

We thank you in advance.

 

 

Prof. Liljana Stevceva

Visiting Professor of Immunology/Clinical Immunology

Prof. Nikola Kamcev

Dean of Faculty of Medicine

University Goce Delcev, Stip, Macedonia

Visiting Professor of ClD

 

 

 

 

 

 

 

IMMUNOLOGICALLY-MEDIATED DISEASES

1. Rheumatic fever and rheumatic disease of the heart

2. Epstien-Barr viral infection 

3. Carcinoma caused by viral infection 

4. AIDS

5. Tuberculosis 

6. Streptococcal glomerulonephritis 

7. Aspergilloma

8. Leishmaniasis

9. Agammaglobulinaemia (Bruton disease) 

10. Hyper IgM syndrome 

11. IgA defficiency

12. Acquired immunodefficiency post splenectomy

13. Anaphylactic reaction

14. Drug allergy

15. Allergy to food

16. Seasonal conjuctivitis

17. Allergic rhinitis

18. Asthma

19. Urticaria

20. Angioedema

21. Atopic egzema

22. Contact dermatitis

23. Multiple sclerosis

24. Guillian-Barre syndrome

25. Leukemia

26. Lymphoma

27. Hodgkin disease

28. Multiple myeloma

29. Infections (especially pneumpnia) because of immunosupression

30. Transplantation

31. Glomerulonephritis

32. Nephrotic syndrome

33. Glomerulosclerosis

34. Amyloidosis 

35. Arthritis 

36. Rheumatoid arthritis 

37. Ankylosing spondylitis 

38. Reiter syndrome 

39. Juvenile idiopathic arthritis

40. Systemic lupus erithematosus

41. Sjorgen’s syndrome

42. Polyartheritis nodosa

43. Polymyalgia rhgeumatica

44. Temporal arteritis

45. Psoriasis

46. ?pemphigus vulgaris

47. Vasculitis

48. Cryoglobulinemia

49. Systemic sclerosis

50. Keratitis

51. Uveitis

52. Allergic bronchopulmonary aspergillosis

53. Extrinsic allergic alveolitis

54. Vegner granulomatosis

55. Takayasu arteritis

56. Pernicious anaemia and atrophic gastritis

57. Celiac disease

58. Crohns disease

59. Ulcerative colitis

60. Viral hepatitis (A, B, C, D, G or E)

61. Primary billiary cirrhosis

62. Thyreotoxicosis (Graves disease)

63. Hashimoto thyreoiditis

64. Myxoedema

65. Diabetes mellitus

66. Addison’s disease

67. Immunologically-mediated infertility

68. Autoimmune hemolytic anemias

69. Paroxysmal nocturnal hemoglobinuria

70. Immune thrombocytopenia

71. Blood transfusion

72. Myastenia Gravis

73. Immunologically-mediated abortion

74. Rh incompatibility

 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

PERMISSION TO BE PHOTOGRAPHED

 

 

I, .....................................................................................................................patient of Dr..................................................................................................................................agree to be photographed and to that photograph to be used for creating seminar thesis and/or publication in a medical journal.

 

Signature                                                                                                            Date

 

 

......................................                                                                        ......................................

 
 
 
 
 
 
Summary of Work

 

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                                                                          ????, J???, 2011

 

 

?????? ???????

??????? ???????? ? ?????????? ?? ?????? ???????????o ?? ???????? ??????? ?? ?????????? ??? ????????-??????????????? ??????????? (???????????? ??? ????????). ????????? ???? ?? ?? ??????????? ?? ???? ??????? ?? ????? ?? ???????. ????????? ???????? ?? ???? ??? ??? ?? ??????? ?? ????????? ??????? ?? ???? ????????.

????????????? ??????????, ?????????? ??? ?? ??????? ????????, e ?????????? ??? ????????? ?? ??????? ?? ????????, ??????? ??????? ???? ??? ?? ?????? ? ??????????, ???????????? ??? ????? ?????????. 

????????? ????????? ????????, ??????? ??????? ??? ?? ??????? ????????, ? ??????????? ?? ?????????? ?? ????????????? ??? ??????????? ?? ??? ????????  ??????? ?????? ???????????? ??? ?????????. ??????????? ???????? ????? ? ????????, ?????? ?? ???????? 24-48 ???? ?? ?????????????. ???????????? ?? ?????? ?????? ?? ????? ????????? ? ???????? ?? ???????? ????, ?? ????????? ?? ????? ?? ?????????, ?? ??? ?? ?????? ???? ?? ??????? ? ?? ???????????????.

?????????? ???????? ?? ????????? ?????????? ??????????: ??????? ??????, ??? ???????,  ????? ?????????, ????? ??? ????? ??????, ?????? , ???????????, ??????? ???? ??? ?? ??????????? ?? ?????????? ?? ??????, ??????? ??????????, ????? ??????, ???? ??? ??????, ?????????, ???????? ? ??????, ??????????, ????????????, ??????, ??????, ??????? ? ????? ????????? ? ??????????.

?????? ???????: ??????? ????????, ??????????, ????????, ????, ????????????, ?????????????.

 

 

Abstract

Contact dermatitis is an inflammation of the skin caused by direct contact with an irritating substance. Contact dermatitis is an inflammation of the skin caused by direct contact with an irritating or allergy-causing substance (irritant or allergen). Reactions may vary in the same person over time. A history of any type of allergies increases the risk for this condition. 

Irritant dermatitis, the most common type of contact dermatitis, involves inflammation resulting from contact with acids, alkaline materials such as soaps and detergents, solvents, or other chemicals. The reaction usually resembles a burn.

Allergic contact dermatitis, the second most common type of contact dermatitis, is caused by exposure to a substance or material to which you have become extra sensitive or allergic. The allergic reaction is often delayed, with the rash appearing 24 - 48 hours after exposure. The skin inflammation varies from mild irritation and redness to open sores, depending on the type of irritant, the body part affected, and your sensitivity.

Common allergens associated with contact dermatitis include: Poison ivy, poison oak, ?ther plants, nickel or other metals, medications, antibiotics, especially those applied to the surface of the skin (topical), topical anesthetics, other medications, rubber or latex, cosmetics, fabrics and clothing,detergents,solvents, adhesives, fragrances, perfumes, other chemicals and substances.

Key words: contact dermatitis, inflammation, allergy, rash, extra sensitive, irritant

 

 

 

 

 

                                                                                   

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1. ????? (Introduction)

??????? ???????? ? ?????????? ?? ?????? ???? ? ???????? ?? ???????? ??????? ?? ???????? ??????????, ???? ?? ?????? ?????, ?????????, ?????. ???? ??? ?? ???????????? ???? ??? ????? ????? ?????? ?? ??????. ???? ????????? ???? ??? ????????? ?? ??????, ??????? ?? ???????? ????????????? ????????? ??????????. ??? ?? ??????? ????????? ???????? ?? ?????? ?? ??????????, ???????  ?? ???????? ????????? ????????? ??????????.

???? ?????? ?? ???????? ????? ??? ??????????? ??? ?? ?? ?????????? ?? ?????, ?????? ????? ?? ????? ? ??????????? ?????? ??????? ?? ????? ??????? ?? ??????????. ?? ???? ?????? ??????????? ??????? ?? ?????? ? ?? ?????? ????? ???????? ??? ???????????? ??????????? ??? ??? ? ????????? ????????? ?? ??? ??? ?? ?????? ??? ?????????  ?????, ??? ?? ???????? ??????? ? ??????? ?? ???????? ???? ?? ??????????. ??? ????????? ?????????? ?? ?????? ????????? ?? ???????? ??????.

2. ???? ?? ???????? (Description of the Case)

?????????? ? ???? ??????? ????????? ???? ???? ?????? ?? ?????? ?? ????? ?????? ?????? ?? ???????? ? ???? ?? ?????? ?? ????? ? ?????????? ?????? ?? ????a?? ?? ??????? ?????? ????? ?? ??????????. ?????? ??????? ???????? ?? ?????? ??? ????????? ????? ???? ???? ??????? ?? ???????? ???? ?? ??????????. ??? ??????? ???? ???????????? ???????? ?? ??????? ???????.

 

 

????? 1 ???????? ?? ???? ??? ??????? ??????????

Figure 1 Redness of skin in contact dermatitis

 

   ????????

?????????- 74 ??????? ?????????, ???????????.

?????? ??????- ?????? ?? ????????, ?????, ?????? ? ??????????? ???? ?? ????? ? ??????????.

??????? ??????- ?????????? ?? ?????? ?? 28.04.2011 ??????, ?? ?????????? ??????? ?? ??????? ?? ?????????? ? ????? ????? ???? ? ?????. ???? ?? ?????? ???????? ?? ?????????? ?????? ??? ??????? ?? ?? ???? ? ??? ?????. ? ?? ???????? ?? ???? ???????? ??????????? ?????????? ?? ????? ?? ????????? ?? ?????? ?? ?????. ???? ??? ???? ?????????? ?? ??????? ?? ?????? ? ??????, ?? ???????? ? ????????????? ???? ?? ???? ?????????? ??????. ?? 5 ???? ?? ???????? ?? ???? ???????? ?? ?????? ??? ????????? ?????. ??? ???? ?? ? ?????????? ??????? ???????? ???? ? ????????? ?? ???????? ???? ?? ??????????. ????????? ?????????? ????????? ???? contact dermatitis dorsi et lumbalis. ????? ??? ???? ??????? ?? ????? ????????????? ? ?????????? ??????????.

 

???????? ?? ???????:

- ????? ????????: ?????????, ??????? ?? ?????? ?? ?????????? ?????? ? ?????

- ????: ?????? ???? ?? ????, ?? ????????? ???????? ????? ?? ??????????

- ????? ? ????: ??????

- ???????????? ??????: ???????? ??????????? ??????,  ??? ????????? ????????

- ???????????????? ??????:  ????????

- ?????????? ??????:  ???????? ?????? ??? ????????? ?????????? ??????

- ???????????? ??????: ???????? ???????, ???????? ???? ? ????? ?? ???????

- ????????????: ?????? ????????? ????????????- ????????????

- ????? ?? ????????? ??????: ???????? ????????

- ??????????? ??????-????? ?? ????????, ?????? ? ?????????? ?????? ??? ?????

- ????????????????? ????????: ???? ????????

?????? ??????????: F41 – ?????? ????????? ? ?????????? ???????????

??????????? ????????: ?????? ???????? ?? ????????? ??????????? ??????????? ??????????

???????????? ????????: ?? ??????? ??????? ????????, ??? ???????? ?? ??????

????? ????????: 74 ??????? ???????, ???????????, ?? ?????? ????????, 2 ????, ?????-?? 5 ?????? ??????, ?????? ??????????? ?? ???????, ????? ?? ???? ?? ????????? ?????.

 

3. ??? ?? ???????? (Development of the case)

?????????, ?????????? ? ?????? ?????? ?? ???????, ?? ????????? ??? ????????? ????? ???? ??????? ?? ?????????? ?? ????????? ???????. ?? ??????????? ??????? ??????? ??? ????????????, ??????????? ???? ??????????????? ?? 04.05.2011. ????????? ?? ?? ?? ???? ??? ????????? ????? ?????? ?? ????, ??????????? ?? ?????????? ??????, ??? ?? ?????? ?? ?????? ???. ???? ???????? ?? ??????, ??????????? ??????? ???????????? ??????? ???? ?????????. ??????????? ?? ??? ????????? ????? ???? ?????????? ???????? ? ?? ??????????????? ???? ???????? ? ?????????? ?? ??????????, ???? ??? ? ? ????????? ????????? Contact dermatitis reg dorsi et lumbalis. ??? ??????? ?? ????????? ???????, ??????????? ???? ??????, ??????????? ?? ???????, ?????  ? ???????? ?? ????? ????? ???????? ? ?????? ?? ????? ?? ??????????, ???????? ? ?????????? ?????? ??? ????????????. ?????????? ?? ??????? ??????? ???? ??????. ?? ?????? ?? ???????? ?? ?????? ??? ????? ?????? ?? ??????? ?????, ??? ?????? ??????????? ?? ????? ?? ??????? ??????, ? ???? ?? ?????? ?? ????? ??? ???? ???? ???????.

 

?? ????????? ? ???????? ???????? ??????????? ???? ??????? ?? ???????? ??????????.  ????????? ??: ??????? ?? ?????, ??????????? ???????, ?????????, ??????????. ?? ????????? ????????? ????????? ? ????: ??????? ?? ??????????? ? ??????, ???? ???? ? ????????????? ??????? (????? 2).

 

 ?????. 2 ????????? ?? ?????????? ?? ??? ? ?????

Figure. 2 Results of examination of blood and urine

 

???? ???? ???????? ? ? ?????????? (????? 3). ???????????? ? ?????????? ??  ??????????????? ?? ?????? ????. ?? ??? ?????????? ?? ???????? ????????? ?? ????????? ?? ?????? ??? ?? ??????? ? ???????, ?????????? ?? ???????? ? ????????? ?? ?????, ?????????? ?? ??????? ????????? ?? ?????, ?????????? ?? ?????? ?? ????? ? ?????????? ?? ?????????? ??????? ?? ??????????? ?? ???????.

 

 

 

????? 3. ??????????

Figure 3. Hepatogram

 

?? ??????????? ????????? ?? ?????????? ? ? ?????????? ???????? ?? Amp.Sinopen, Ung. Decotal I Amp. Ketonal ?? ???????.

?? ?????????? ? ??????????? ???????, ??????????? ???? ????????? ??  10.05.2011 ?? ????????? Contact dermatitis reg dorsi et lumbalis (??? – 10 ??-12). ?? ??????? ???????? ? ? ????????? ???? Decotal, ?? ?? ???????? ??? ???? ??????, ? ?????????? ? ? ???????? ?? ???? ?????? ?? ???????????.

 

 

????? 4. ??????? ?????

Figure 4. Discharge Summary

 

4. ??????? ?? ??????? (Description of the Disease)

???????, ??????????? ??? ????????? ????????? ?? ????????? ????? ????? ?? ??????? ?? ???????? ?? ??????????. ???????? ????? ???? ?? ??????????? ??? ???? ?? ??????? ?? ????????? ????????, ??? ??? ??????? ?? ??????? ?? ????? ????????? ? ??????. ??????????? ???????? ?????????? ?????? ??? ???????? ?????????? ??? ????????? ??? ??????? ?? ???????, ???????? ? ????????? ?????. ?????? ?????????? ?? ??????????? ??????????  ???? ?? ?? ?????? ?? : 

 

????????????? ????????? ???????? ???

????????? ????????? ????????.

 

 

 

????? 5 ????????????? ? ????????? ????????? ??????????

Figure 5. Irritant and allergic contact dermatitis

 

??? ???????????? ?????? ?????????? ?? ??????? ???????? (??? ?? ????? ?????? ?????? ??????? ??????????) ?? ?????????????? ????????? ????????, ?? ??? ????? ? ?????????????? ??????????? ? ??????? ?? ??????????? ????????? ???? ?? ?? ?????? ????????? ????????? ?? ????? ?? 4 ?? 24 ????. 

??? ????? ???? ???????????? ???? ?? ?? ?????? ?? ???????????? ???????? ?? ???????? ????????? ??? ??????? ?? ?????????????? ??????? ???????. ???? ? ???????, ??????? ? ????????? ??? ?? ???????? ?? ?????? ?? ?????????? ???? ?? ???????????? ????????? ????????. ????? 10 %  ?? ?????? ?? ????????? ?? ????? ??? ??? ? ???? ?????????? ?? ????????????.

???????? ??????? ?? ?????? ?? ????????? ???????? ??: 

 

1. ?????????? ?????????

????????? ?? ???????????? ?? ?????, ??? ?? ?????, ???????? ?? ???????????? ?? ??? ?? ????? (??????), ???????????, ??????????, ???????, ???????, ???????? ?? ??????? ?? ????? ???.

2. ??????

?????

3. ?????

??????? ??????, ???????, ??????? ? ??.

 

4. ?????? ? ????? ?? ????

??????????? (??????????, ???????????, ????????)

??????????????? (?????????????, ??????????)

?????????? (?????????)

??????????? (?????????)

?????????????

5. ????????? ??? ?? ???????????? ?? ?????????????? ??????????

???????? ?? ?????, ???????????? ?? ???? ? ??????????????? ?? ???????? ????????, ???????, ???????? ? ??.

   

   

????? 6 ??????????? ?? ????????? ??????????

Figure 6 Causative agents of contact dermatitis

 

?????????? ?? ??????????? ?????????? ?? ???????? ???? ????? ???????????? ????????, ??? ??? ???? ????? ????? ?? ?????. ??? ???????? ????? ????? ?? ?????????? ???? ?? ???????????? ???? ?? ??????, ??????? ????????? ?? ???????????? ???? ?? ??????? ?? ????????? ? ????? ?? ??????????, ?? ????????? ?? ???????, ? ????? ????? ?? ?? ???????? ? ?? ?????? ????. ?????? ? ??????, ????? ???????, ?? ????? ?????? ?? ???????? (????????), ????????? ?? ?????? ??? ??????? ???????, ?? ??? ????????? ?????? ????????? ??????? ?? ?????????? ? ???????? ?? ???????? ?? ???. ???? ???? ????? ? ?? ?????? ? ?????? ?? ??????. ???????? ?? ???? ?? ???? ???? ????????, ???? ?????? ?? ?????? ??????? ?? ??????? ? ??????. ??????? ??????????????? ?? ?????? ?? ????????, ?????????? ?????? ????????? ?? ??????? ????. ?????????? ???????? ?? ?????????? ?? ?????? ??? ???? ?? ?????. ?? ????? ?? ?????????? ?? ???????? ?????? ????????? ?? ??????, ??????, ? ?????????? ???????????? ?? ?????? ??? ???? ?? ???? ?? ??????, ?? ???? ? ?? ?????? ???????.

 

?????????? ?? ?????????? ????????? ????????:

????????????? ????????? ???????? ? ???????? ???????? ?? ?????????? ??? ??????????? ?? ????????? ?? ????????????????? ???????? ?? ???????? ?? ?????? (?????? ????????????), ?????? ???? ??????? ?? ??????? ??????????. ???????? ???????? ????? ????? ?? ?????????? ???? ???????? ?? 3 ?????? ?????????????? ??????? ?? ?????? ???????? ??????????, ??????????? ???????? ???????, ???? ? ???????????? ?? ????????.

?? ??????? ????????????? ??? ?????? ?? ???????????, ????? ??????? ?? ????????? ????? ?? ??????????? ???? ????? ????????????. ???????? ????? ???????????? ?????????? ????????????, ???????????, ????????? ? ?????????????.

?????????????? ?????????????? ????? ?????????, ??????? ???  ???????????? ?? ?????? ????? ? ????? ??? ?? ?? ????????? ???????, ?? ??? ?? ????????? ???????????????? ?????? ?? ???? ? ?? ????? ?????? ???????? ?? ????????? ???????? ?????????? ?????? ?? ??????? ????????? ????? ?????????? ????? ???????????. ??????? ???????? ? ??????? ?????????? ?? ?????? ?? ??????????? ??????? ??????.

????????????? ???? ?? ?????????? ????????? ?? ??????. ??????? ?????? ? ?? ?????????, ??? ???? ?? ????????? ???????? ?? ????????? ??????? ?????????? ?? ???????? ????????. ????? ?????????? ??????? ? ????? ????? ???? ??????? ??? ????????????? ???????? ????? ??????.

????????? ?? ?????? ? ?????????????? ?? ?? ?????? ????? ?????????????? ?? ???????? ??????. ????????? ?? ?????? ?? ??????????? ??? ????????? ??????????? ???????? ?? ?????????? ????????? ? ????????? ?? ??????????????? ??????. 

???????????? ?? ??????????????? ????????? ???????? ?? ???????? ????????????? ??????, ??????? ???????????, ??????????? ?????? ?????? ????????? ??? ??? ???????? ?? ??????? ?? ???????? ? ????????? ?????????? ???????????? ???? ?? ?????. ?????????????? ?????? ????? ????? ?? ??????????? ? ?????????????? ?? ??????? ???????????? ??????? ????? ???????????? ?? ????????. ?????????????? ????????????? ????? ???????? ?????????????.

????? ???? ?? ???????? ??????? (?? ??????, ?????????????? ????????, ????????? ??????) ???? ?? ???????????? ????????????? ???????????? ?? ?? ?????????  ???????? ????????:

?????????????? ???????? (??????????? 1, ???????? ???????? ??????-????)

???????????? ???????? (??????????? 8, ??????????? 10) 

???????? ?? ???? (??????????? 6, ??????????? 7, ??????????? 15, ????????????-??????????? ????????-???????????? ??????, ?????????????? ?? ???????? ?? ????-????)

???????? ?????a???? ?? ??????????? ? ?????????? ???????? (??????????? 10, ??????????? 12, ??????????? 18)

 

 

 

????? 7 ?????????? ?? ????????? ????????

Figure 7 Pathogenesis of contact dermatitis

 

??????????????? ?? ????????? ????????? ??????????. ???? ?? ??????????????? (????????? ????) (????). ????????? ????e?????? ?? ??????????? (????? 1) ? ?? ????????? ?? ?????? ?? ????????????? ??????. ????????????? ?????? (DCS) ????????? ?? ?????????? ?????? ????? (????? 2), ???? ??? ?? ???????????? ?????? ????????? ?? ??8+ ????????? ? ?????? ? ????????????? ??4+ T ?????? (????? 3). ?????????? ? ?????? ?????????? ??????? ?? ???????????? ?? ?????????? ?????? ?????, ????????????? ????? ?????, ? ????????? ?? ???????, ??????????? ?? ? ?????? (????? 4). (?????) ???? ?? ??????????? (???? ?? ?????????, ????????? ????). ???? ?????? ?????? ?? ???????? ?? ??????, ??? ? ????????? ?? ?????? ?? ????????????? ??????, ??????????? ?? ? ??????? ??????????? ?????? ? ?????????????? (????? 5), ??? ?? ???????????? ?????? ????????? ?? ???????????? ? ??????. ???????????? ?? ??8+ ???????????? ? ????????? ?????????? ?????????? ?? ?????????????? ? ?????????? ?? ???????? ? ???????? ?? ?????? ?? ??????? ?????? (????? 6). ??? ???????? ?? ????????? ?? ????????? ?? ????? ?? ??????. ??4+ T ?????? ???? ?? ?? ????????? ????????????/???????????? ?? ??8+ ???????? ?? ???????? ????? ?? ????? ?? ?????? ?? ?????????? ? ?? ?????? ?? ????? ?? ?????? ?? ??????????? ??  ??????????? ????????????????? (???????? 3 ? 7). 

?????????????? ????????? ???????? 1 ????????? ???????????? ?? ????????? ?? ??????????? ? ??????? ???????????? ????????. ?????????? ???????? ???? ???????????? ?? ????? ?? ???????? 48 ? 96 ???? ?? ???????????? ?? ???????? ????????? ????? ??????? ?????? ?????? (??? ?? ??????? ?? ???????, ????????? ?? ??????? ?? ??????, ???? ?????????? ? ??????? ?? ???? ? ?? ????????????? ???? ??????????????? ???????????).

 

?????????? ?? ????????? ????????? ????????:

????? 3000 ????????? ?? ????? ????????????? ?? ?????????? ??????? ?? ????????? ????????? ??????????. ???????? ?? ??????????? ??? ????? ?? ???????????? ????????? ????????? ?????????? ?? ???? ???????? (<500 ?). ???? ???????? ????? ?? ?? ????? ?? ?????????? ?? ??????????????? ??????, ??? ?? ??????? ?? ??????? ?? ???????????????? ???? ?? ???????????.

??????????????? ?????? ?? ???????-????????????? ?????? ?? ?????? ??? ???????????? ??4+ T ?????? (? ?????? ??????????). ???????????? ?????? ??????? ?? ???????? ?????????, ???????? ??????? ??? ?????????? ????????.  ???????????? ?????? ?? ???????? ?? ?? ??????????? ???????? ?????? ???? ???????. ???? ????????? ???????? ????? ?? ???????? ??????????????? ????????. 

??????? ?????????? ?? ???????????? ???? ?? ???????????? ????????????? ?? ??????, ???? ??? ?? ??????? ?? ???????? ??????????. ????????, ??? ?????????????? ?????????? ?????????? ??????? ??????, ??????? ??? ? ????? ?????????.

????? ????? ?????????? ????? ?? ??????????? ????????? ???????, ??????????? ??? ?? ???? ??? ????? ???????, ???? ?? ????? ?? ????? ? ?????; ??? ?????? ?? ????, ?????? ???? ? ????????? ???????, ??????? ??? ??????. ?????? ?????? ?? ??????, ???????, ???????, ??????? ? ????????? ???? ???? ???? ?? ??????????? ????????.

????????? ?? ?????? ? ?? ??????????? ? ?? ??????????? ??????????? ???????? ?? ????????? ? ?????????? ????????? ?? ??????????????? ??????. ????????? ?? ???, ???? ??????????? ??????????? ?????????????? ?????????? ????????? ?? ??1a+ ??83+ ????????????? ?????? ?? ??????? ????????? ??? ??????????? ????????????.

??????????, ???? ????, ?????? ????? ????? ???  ??????????? ????????? ??????????, ??????? ?? ?????????? ??????????? ????????, ???? ??? ? ?????????????? ????????? ???????? 1. ??????????? 8 ???? ?? ???? ???????? ? ??????? ?? ????????? ????????? ??????????, ? ?? ????????????? ????????? ??????????.

????????? ??????????????? ?????? ???? 10-14 ???? ?? ????? ?? ????????? ?????????? ?? ????? ????????? ???????. ??? ????????  ??????????, ????? ???????? ????????? ??????? ?????????? ?? ????????? ?? ??? ?? ???????? ??????, ?? ??????, ?????????????? ?? ??????? ?? ?????? ?? ?????? ???? ?? ?? ?????? ??? ?????? ?? ???????? ??????????? ????????? ???????? ???? ???????? ?? ??????? ????????? ?? ??????. ??? ???????? ???????? ?? ?????????, ????????? ????????? ?????????? ?? ??????? ??????? ???? ?? ??????? ???? ?? ??????????.

??4+ CCR10+ ????????? ?-?????? ???????? ?? ???????? ?? ???????? ?????????? ?? ????????? ????????? ??????????.

 

????????? ?? ????????? ??????????

?? ?? ?????? ???????????? ?? ??????????? ???????? ?? ??????? ? ?????, ??????? ?????? ?? ?? ?????? ?? ??? ???????? ??????? ?? ??????? ? ?? ??? ???????? ?? ?????????. ????? ?????? ??????????? ?? ????????? ?? ????????? ???????? ? ?????????????? ?? ?????? ????. ??????? ??????? ?? ????????? ?? ????????? ????????, ?? ????? ?? ???? ?? ?? ???????? ??????????? ??????????, ?? ??? ?????? ?? ?????? ??????? ?? ??????? ???????. ?????? ????, ?? ???????? ?? ??? ????? ???, ??????? ?? ??????? ?? ??????? ????????? ??? ?? ???? ??????? ?????????? ?????? ??? ?? ???????? ?????????????? ?? ????????????. ?? ??? ???? ?? ????? ???? ??? ?????? ?? ???????? ??? ?????? ?? ???? ??????? ? ?? ??? ????? ??????? ?????? ?? ?????? ????????? ???????? ?? ???????? ??????????????? ?? ??????. ?? ????? ??????????? ?? ????????? ? ????????????. ???????? ????? ?????? ?? ???? ??? ?? ???????? ? ????? ?? ???  ??  ?????  ????????? ??? ???????????? ? ???? ?????? ???? ????? ?? ???? ????????. ????? ??? ??????????? ?? ????????? ?? ??????? ????? ????? ?? ?? ????????????. ????????? ????? ?? ????? ????? ???????? ??? ????? ?????????. ?? ????????? ??????????? ?? ??????? ???????????, ??????????? ???????? ???? ?? ?? ?????? ? ??? ??????? ?? ????????? ?? ???????. ?? ??????????? ?? ??????? ???? ?? ???? ???????? ???????? ?? ????????? ?? ?????????????.

 

 

 

????? 8 ???? ???????

Figure 8 Test Patch

 

????????

???????? ?? ?????????? ?? ???????????? ?? ????????????? ??? ??????????? ?? ?? ??? ??? ???????????? ????????? ????????. ?? ?? ?? ?????? ???????? ?? ?????????? ?????????, ??????? ???????? ?? ??????????? ???????? ???????? ? ??????? ?? ?? ?????? ?? ???? ? ?????. ?? ???? ?? ?? ???? ??????? ?????? ?? ???????. ??????????? ???? ?? ?? ?????? ?? ??????????? ?? ?????? ?? ???????? ????????? ?? ????????. ?????????????????? ????? ? ????? ?? ?????????? ?????????? ?? ??????? ?????????  ????????, ? ??? ????????? ?????? ???????? ? ?? ?? ??? ? ???????????????? ???????? ?? ??. Prednizon. ?? ???????? ?????? ????????????????? ?? ?????????? ???????, ?? ????? ??????? ??????? ?? ? ????? ????????.

 

5. ???????? (Conclusion)

?????? ?? ????????? ???? ??????????? ?????????? ?? ????????????? ?? ???? ??? ???? ?? ?? ????? ???????? ?? ?????? (???????? ?? ?????? ? ??????) ? ? ??????????? ?? ????? ??? ????? ?? ??????? ?? ??????, ??? ???????? ?? ????????? ????????. ?? ??????????? ?????? ??????? ????, ?????? ? ?????????. ?? ????? ??????, ???? ?????? ?? ????? ???? ?????? ?????????? ? ??????? ?? ?????? ?? ??????????, ?? ??? ???? ?? ?? ?????? ??????? ?? ?????? ? ?? ?? ????????? ???????? ????? ?? ????????. ??????? ?????????? ?????? ?????????? ??? ??????????? ?? ??? ?? 2 ??? 3 ??????, ?? ???? ?? ?? ????? ??? ????????????? ??? ??????????? ??? ?? ???????????? ?? ???? ?? ?? ???????????? ? ?????????. ??????? ?? ???????? ??? ????????????? ?????? ???? ?? ????? ????????? ??? ???????????? ? ???????????? ?? ??????????? ?? ????????? ?????.

 

6. ????????? ?????????? (Bibliography)

1. Gober MD, DeCapite TJ, Gaspari AA. Contact dermatitis. In: Adkinson NF Jr, ed.    Middleton’s Allergy: Principles and Practice. 7th ed. Philadelphia, Pa: Mosby Elsevier; 2008:chap 63.

2. Habif TP. Contact dermatitis and patch testing. In: Habif TP, ed. Clinical Dermatology. 5th ed. Philadelphia, Pa: Mosby Elsevier; 2009:chap 4

3. Daniel J Hogan, MD  Clinical Professor of Internal Medicine (Dermatology), Nova Southeastern University College of Osteopathic Medicine; Investigator, Hill Top Research, Florida Research Center

4. Samuel Weinberg, Neil S. Prose, Leonard Kristal, Color Atlas of Pediatric Dermatology??Copyright 2008, McGraw-Hill Companies, Inc. 

5. Hennino A, Vocanson M, Chavagnac C et al. (2005) Update on the pathophysiology with special emphasis on CD8 effector T cells and CD4 regulatory T cells. An Bras Dermatol 80:335–47

6. Elliott G, Das PK. (2010)Defining the antigen determinant for T-cell-mediated contact dermatitis using p-phenylenediamine: a gateway to chemical immunology. J Invest Dermatol. Mar;130(3):641-3. 

7.http://www.emedicinehealth.com/contact_dermatitis/article_em.htm#Contact%20Dermatitis%20Overview

8.http://trialx.com/curebyte/2011/05/27/contact-dermatitis-photos-and-a-listing-of-clinical-trials/

9.http://www.emedicinehealth.com/contact_dermatitis/page3_em.htm#Contact Dermatitis Symptoms

10. http://www.trinityallergy.com/webdocspublic/Contact-Dermatitis.pdf

11. http://www.skincareguide.ca/images/glossary/photo_contact_dermatitis.jpg

12. http://heatrashpictures.com/images/contact_dermatitis_2.jpg

13. http://www.nachi.org/images10/rash.jpg

14. Aleksic M, Pease CK, Basketter DA et al. (2007) Investigating protein haptenation mechanisms of skin sensitizers using human serum albumin as a model protein. Toxicol In Vitro 21:723–33

 

Conclusion
Take-home Messages
Acknowledgement
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